Semaglutide, generally identified beneath the model names Ozempic and Wegovy, has taken the burden loss world by storm. And, because it helps with weight reduction, it’s good for sort 2 diabetes, as weight reduction is the first method to reverse the signs of sort 2 diabetes. Semaglutide does cut back urge for food since you really feel fuller longer. Nevertheless, it isn’t a miracle treatment, and it comes with negative effects. I’ve written beforehand about Ozempic face, weight reduction plateaus, regaining weight after you cease Ozempic, ineffectiveness for some individuals, in addition to pure alternate options and fiber-rich meals that naturally work like semaglutide, simply to a lesser diploma. However now a brand new facet impact is rising—SIBO (small intestinal bacterial overgrowth). So, let’s take a better have a look at this.
Understanding SIBO and Its Connection to Semaglutide
SIBO happens when extreme micro organism develop within the small gut, resulting in signs like bloating, diarrhea, stomach ache, and meals intolerances. An absence of intestine motility could also be a part of the reason for SIBO, together with a low manufacturing of hydrochloric acid within the abdomen. Ultimately, the pure defenses of the small gut are compromised, and SIBO outcomes.
The Revealed Case Report of SIBO and Semaglutide
A case report printed in Canadian Journal of Physiology and Pharmacology describes a 35-year-old male who managed to lose 50 kilos ( 22.7 kg) over 120 days on oral semaglutide. Although he had earlier lactose intolerance, it acquired worse whereas taking semaglutide. And he additionally developed a brand new gluten intolerance. Then about six months after discontinuing semaglutide, he was identified with SIBO, suggesting the drug might have contributed to or made this situation worse. The truth that the meals intolerances didn’t simply go away when he stopped taking semaglutide is very regarding. Apparently, there was a change each within the GI tract motility and the micro organism that enjoyed these circumstances that continued after the drug was stopped.
How Semaglutide May Contribute to SIBO
Semaglutide’s predominant impact is slowing down the emptying of the abdomen and slowing down intestinal transit. That impact makes you are feeling full longer for sue, but it surely additionally creates the right surroundings for micro organism to proliferate within the small gut. Micro organism die-off within the abdomen isn’t excellent, and the micro organism load may be substantial. So, even when 1 in 10,000 micro organism get by means of, however they get to hang around within the small gut and adapt resistance to bile salts, then they’ll colonize the small gut and reside off the sugars and brief chain carbohydrates that come their means.
This case report is simply from one man, however anecdotal studies from different clinicians counsel that is removed from the one case. If you have already got sort 2 diabetes, and have any type of meals intolerances, this new facet impact ought to offer you pause. Do you actually wish to take care of SIBO?
Semaglutide’s Facet Impact Listing is Getting Longer
In our earlier articles about weight reduction and semaglutide, we’ve lined a number of negative effects related to semaglutide. “Ozempic Face: Methods to Lose Weight With out Trying Older” mentioned the gaunt, aged look some customers expertise as a consequence of speedy fats and muscle loss when taking semaglutide. “Methods to Overcome a Weight Loss Plateau” explored why progress stalls for some. Within the article “Battling Ozempic Not Working? Right here’s Methods to Repair It” I talked about how Ozempic doesn’t work for everyone, and the widespread myths that folks consider about weight reduction medicine. I didn’t discuss in regards to the uncommon negative effects like elevated threat of pancreatitis.
SIBO provides a complete new type of facet impact to the listing. Not like beauty issues about Ozempic face, or plateauing weight reduction, SIBO actually impacts your high quality of life. It’s in all probability worse than the diabetes itself. It’s essential to no less than briefly use a low FODMAP food plan to handle the bloating and diarrhea. It’s a very restrictive food plan and doesn’t actually assist you to get higher both.
For some individuals, the trade-off of simple weight reduction with Ozempic for a continual case of SIBO. I do know a couple of individuals who have struggled with SIBO for years and nonetheless haven’t overcome it. I believe coping with sort 2 diabetes is way simpler than overcoming SIBO. Attempting to alter entrenched micro organism within the intestinal tract is a troublesome proposition.
We’ve got a number of articles about concepts for sustainable weight reduction. You possibly can see an outline of them within the article, “The Full Information to Wholesome Weight Loss: What Works and Why.” In spite of everything, even with weigh loss medicine, to achieve success long-term you need to study to eat wholesome meals, and get train to keep up weight reduction.
Conclusion: Is Semaglutide Definitely worth the Dangers?
Semaglutide is a robust drug for serving to individuals drop some weight. However it has drawbacks. If you find yourself with SIBO, you might need wished that you just had by no means taken the drug to start out with. It isn’t identified but how prevalent the incidence of SIBO is with semaglutide use. But when you have already got meals intolerances, you in all probability have a better likelihood of SIBO with the drug.
As talked about above, it’s best to take a look at our information on sustainable weight reduction suggestions. There are alternate options to occurring a crash course with Ozempic.
